lookindex

KPV

Also known as Lys-Pro-Val, alpha-MSH (11-13)

A tiny fragment of a natural skin hormone with real anti-inflammatory effects in mice. Nobody has tested whether it helps skin or gut problems in people.

Information only. Not medical advice. Talk to a doctor before you start, stop or change anything.

What people claim

  • Calms skin inflammation and acne
  • Heals the gut
  • Antimicrobial

What the evidence shows

  • In two mouse models of colitis, it reduced inflammation and weight loss.[1]
  • Lab and animal work suggests anti-inflammatory and antimicrobial effects in skin.[2]
  • FDA says it found no human exposure data for any route, so it cannot know whether it causes harm.[3]

Known risks

  • No human safety data exists for any route.[3]
  • Mouse results often fail to carry over to people.[1]

Reported side effects

Moderated user reports are not open yet, so nothing is shown here. They will be labelled as unverified personal accounts.

Legal status

A summary, not legal advice. Rules change, and sport bans are separate.

United States

Unapproved, compounding tolerated

Included in the October 2026 HHS interim policy for topical and oral compounding on a patient-specific prescription. It is not FDA approval.[4]

United Kingdom

Unlicensed

No licensed medicine contains it.

Australia

Not approved

TGA says importing, advertising or supplying unapproved peptides is unlawful.[5]

European Union

Not authorised

No authorised medicine. National rules on possession and import differ.

Sources

  1. 1.Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of IBDInflammatory Bowel Diseases, 2008
  2. 2.Alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugsReview, PubMed Central
  3. 3.Bulk drug substances that may present significant safety risksUS FDA
  4. 4.HHS interim enforcement discretion policy for six peptides (legal summary)Holland & Knight, Nov 2026
  5. 5.Importing, compounding and supplying unapproved peptide productsTGA Australia

Profile last checked 7 Nov 2026.